Speaker 2: Celso Arango
نویسندگان
چکیده
Immune molecules and redox pathways are receiving increasing attention for a possible role in pathophysiology of psychiatric disorders. A cell population that may present enhanced vulnerability to the deleterious effects of these mechanisms is the parvalbumin-positive fast spiking interneurons in cortical circuits. This cell population is thought to be affected in schizophrenia, as post-mortem data consistently reveals changes that can be explained by loss of function in these neurons. Remarkably, several different animal models that produce schizophreniarelevant behavioural deficits such as altered prepulse inhibition of the acoustic startle response converge in showing alterations in this interneuron population. We explored whether oxidative stress was present and whether antioxidant treatment could reverse deficits in one such model, rats with a neonatal ventral hippocampal lesion (NVHL). This model produces animals
منابع مشابه
Association between relative temporal and prefrontal sulcal 2 cerebrospinal f luid and illness duration in schizophrenia
5 Rogelio Luque , Tomás Palomo , Celso Arango , Manuel Desco b 6 Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Avda de Córdoba, km 5.4, 28041 Madrid, Spain 7 Department of Experimental Medicine, Hospital ‘‘Gregorio Marañón’’, Madrid, Spain 8 Department of Neuroradiology, Hospital ‘‘Gregorio Marañón’’, Madrid, Spain 9 Department of Psychiatry, Hospital ‘‘G...
متن کاملThe Madrid Declaration: why we need a coordinated Europe-wide effort in mental health research.
The Madrid Declaration is being promoted by representatives from seven nationally funded mental health research networks, along with leaders of ongoing European Union-funded mental health projects. It advocates the creation of a Network of Excellent Networks, based on a dynamic and adaptive cross-European network of distinctly qualified research centres.
متن کاملTrait and state attributes of insight in first episodes of early-onset schizophrenia and other psychoses: a 2-year longitudinal study.
BACKGROUND Increasing evidence supports the important role of illness state and individual characteristics in insight. METHODS Insight, as measured with the Scale to Assess Unawareness of Mental Disorder, over the first 2 years of early-onset first-episode psychosis and its correlations with clinical, socio-demographic, cognitive, and structural brain variables are studied. RESULTS (1) insi...
متن کامل